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Aerobic respiration primarily occurs in the mitochondria, which are often referred to as the "powerhouses" of the cell. This process requires oxygen and generates energy by converting glucose and other substrates into adenosine triphosphate (ATP), the energy currency of the cell. Mitochondria contain the necessary enzymes and structures for the Krebs cycle and oxidative phosphorylation, which are key stages of aerobic respiration.

In contrast, the ribosomes are responsible for protein synthesis, the cell membrane serves as a barrier and regulates the entry and exit of substances, and the nucleus houses genetic material and is involved in the regulation of gene expression. Thus, the mitochondria are specifically designed to facilitate the energy production that characterizes aerobic respiration, making them the correct location for this process.

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